Ro 13-9904: affinity for penicillin binding proteins and effect on cell wall synthesis.
نویسندگان
چکیده
Studies on the binding of Ro 13-9904, a new broad-spectrum cephalosporin, showed that it had higher affinities for PBPs 1b, 2, and 3 of Escherichia coil (3> 1b>2) than cefazolin, cephaloridine, cephalothin or cephalexin. With Haemophilus inf uenzae, Ro 13-9904 showed highest affinities for PBPS4 and 5 followed by PBP 2. It inhibited total cell wall synthesis at lower concentrations than the other 8-lactam antibiotics tested.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 34 5 شماره
صفحات -
تاریخ انتشار 1981